Pure nongestational choriocarcinoma of the ovary in a child: Case report
Şemsi ALTANER, Ebru TAŞTEKİN, Burhan AKSU, Fulya ÖZ PUYAN, Kemal KUTLU
Trakya Üniversitesi Tıp Fakültesi Patoloji ve Çocuk Cerrahisi Anabilim Dalları, Edirne
Keywords: Choriocarcinoma, Ovary
Abstract
A 9-year-old girl was admitted to our hospital with abdominal pain and distention due to a complex ovarian mass. An ultrasound scan showed a 7x5x5 cm, intensive fluid loculation and septation in right inferior quadran pericheacecal area. Radiologist reported this massas an abscess formation. The laboratory data showed high serum level of HCG. The level of FSH, estrodiol, LH, total testesteron, androstenodion, CEA, AFP ve 17-OH progesteron were normal. An emergency surgery was planned with these findings. Right salpingoophorectomy, and left ovary wedge resection and lymph node dissection were performed. The right ovary revealed a cystic, necrosis and hemorrhagic tumor with solid parts. The microscopic examination containing wide areas of necrosis and hemorrhagic in which atypical cytotrophoblastic and syncitiotrophoblastic cells are observed. Syncitiotrophoblastic cells was immunohistochemically diffuse positive for HCG. Furthermore, It was focally positive for inhibin and diffuse positive for keratin. CD99, CD30, CEA, NSE, PLAP, AFP were negative. We present a case of a 9-year-old girl diagnosed with pure nongestational choriocarcinoma of the ovary with a review of the literature.