Abstract

Objective: Burn eschar treatment delays the healing period and usually needs surgical intervention. Alternatively, enzymatic debridement materials are widely used and effective. However, these agents are bacteria originated and this limits antimicrobial agent use.

In this study we aimed to evaluate the efficacy of collagenase used with antimicrobial agents observing changes in systemic inflamatory symptoms .

Materials and Methods: Superficial and deep second degree burn patients between 2011-2013 were examined retrospectively.78 patients were divided into 2 groups : Only collagenase group, and collagenase with antimicrobial agents (Patch method) group. Demographics and recovery data were recorded and statiscally analyzed.

Results: Surgical intervention ratios for Collagenase and Patch groups were 29.2 % , 46.7 % respectively. Mean escharolysis time in The Collagenase and The Patch groups were 7.2 ± 3.3 , 9,6± 2.8 days respectively. Mean time of epithelization start in Collagenase and Patch groups were 12.3 ± 5.8, 13.4 ± 4.8 days respectively. Systemic inflammatory symptoms ratio in The Collagenase and the Patch group were 27.1% and 43.3% respectively. The only statistically significant difference was on the time of escharolysis.

Conclusion: The Patch method delays escharolysis period, but does not inhibit it. So it can be used safely.

Cite as: Görkem Bulut, Ülküm Zafer Dökümcü, Emre Divarcı, Ahmet Çelik, Geylani Özok. The Effıccacy of Clostiridial Colleganase Coated With Antımıcrobıal Agents On Burn Patients. Coc Cer Derg/Turkish J Ped Surg 2022;36(2): 34-36. doi: 10.29228/JTAPS.58181