The importance of genetic analysis in patient with dysgerminoma !
Gülşen Ekingen 1, Gülcan Çetin 3, Kıvılcım Karaoğlu 1, Burak Erkuş 1, Bahar Müezzeinoğlu 2
1Kocaeli Üniversitesi Tıp Fakültesi Çocuk Cerrahisi Anabilim Dalı, Adapazarı
2Kocaeli Üniversitesi Tıp Fakültesi Çocuk Patoloji Anabilim Dalı, Adapazarı
3Sakarya Kadın Doğum ve Çocuk Hastanesi, Adapazarı
Keywords: Dysgerminoma, Swyer Syndrome, gonadal dysgenesis
Abstract
Dysgerminoma of ovary is the most common malign germ cell tumor, accounting for 50% of the cases with germ cell tumors. Bilateral ovarian dysgerminoma is very rare. However this condition is seen in individuals with gonadal dysgenesis and Swyer syndrome Since 5 % of dysgerminomas are discovered in individuals with a female phenotype and 46 XY karyotype, in adolescents with dysgerminomas and complaints of amenorrhea, karyotypic gene analysis should be done. In addition fertility sparing operative treatment should be preferred when her chromosomal structure is normal.
We aimed to discuss the importance of genetic analysis in medical and surgical therapeutic approaches in two patients with bilateral dysgerminomas.