Abstract

Aim: To investigate the late testicular effects of spermatic cord torsion and role of diclofenac on testicular injury.

Material and Methods: In the first group (G1) of rats detorsion followed 4 hours of left testis torsion. For the second group (G2), detorsion followed 4 hours of torsion and diclofenac (2,5 mg/kg IM) administration. For the last group (G3), detorsion was performed after 4 hours of torsion and combined Diclofenac and Verapamil (10 mg/kg/IM) administration. Bilateral orchiectomy was done after 4 weeks. Spermatogenic activity and diameter of seminiferious tubules were evaluated.

Results: When testicular weights were evaluated, the most significant increase was detected in the Diclofenac Group, whereas Verapamile group showed significant decrease both in the ipsilateral and contralateral testes. There were significant differences between ‘G1 and G2’ (p:0,002), ‘G1 and G3’ (p:0,04) and ‘G2 and G3’ (p:0,02) by means of seminiferious tubule diameters of torsioned testes. The most prominent increases in diameters were in the Diclofenac Group. We found significant differences for the seminiferious tubule diameters of the contralateral testes in between ‘G1 and G3’ (p:0,03) and ‘G2 and G3’ (p:0,003). Significant differences were found by means of spermatogenic activity of the torsioned testes between ‘G1 and G2’ (p:0.005), ‘G1 and G3’ (p:0.004), and ‘G2 and G3’(p:0.02) groups. For the contralateral testes; the differences between ‘G1 and G2’(p:0.003) and ‘G1 and G3’ (p:0.007)were significant.

Conclusion: Unilateral testicular torsion-detorsion causes permanent damage in ipsilateral testes. Diclofenac partially prevented this injury. After sufficient investigations, its use in patients with testicular torsion can be beneficial.